One of the nine people killed in the small plane crash in Florida on Sunday has been identified as 40-year-old Helen Sharp, who was a University of Arizona alum. Sharp’s father told AZFamily she attended the university before returning to Texas, where she was from. Sharp was on the jet with her husband, Adam Robinson, their children, 4-year-old Emma and 2-year-old Charlie, and their nanny, Anita Maria Cetina. The family was also traveling with two friends, Rachael Reed and Charmi Fehr. Who else was on the plane? A 20-year-old woman who had been a licensed pilot since she was a teenager and a technology entrepreneur and his family were among nine people killed when the small jet crashed, family members said. Nathalia Gadelha Filgueiras was the copilot flying a Learjet from Austin, Texas, to the Bahamas, on Sunday when it crashed and exploded near West Palm Beach, her mother Camila Corteleti told the New York Post and New York Times. Filgueiras earned her license in 2023 when she was a 17-year-old senior at West Boca Raton Community High School, according to local news reports at the time. The identity of the other pilot was not immediately disclosed. The Associated Press contributed to this report.

Dylan Harper scored 17 points to lead a balanced attack that saw all five San Antonio starters score in double figures as the host Spurs rolled to a 1

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Jalin Holland had 18 points and six rebounds to help Colorado run away with a 94-59 win against Abilene Christian in the season opener for both teams

This is for Project Operations Core and Integrated to ERP. Enable project managers to compare multiple budget versions and select the most suitable budget before submission and approval. This capability improves decision-making by allowing users to evaluate different planning scenarios, understand financial impacts, and confidently choose the preferred budget version.GA date: August CY2027Preview date: March CY2027

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BackgroundMicroplastics (MPs) are widely prevalent in the environment and food chain, leading to increased human exposure and potential health risks. Although MPs have been shown to induce reproductive toxicity in animal models, it remains unclear whether exposure to MPs contributes to the decline in human semen quality. This study aimed to investigate the association between MP exposure and semen quality among men visiting assisted reproductive outpatient clinics at tertiary hospitals.MethodsThis study employed both cross-sectional and case–control designs. The study population comprised men attending the assisted reproductive outpatient clinic of a Grade-A tertiary hospital in Jinan, China, between April 1 and July 31, 2023. Semen quality parameters were assessed using an automated sperm analyzer. Fecal microplastic (MP) levels were quantified via laser direct infrared spectroscopy, and gut microbiota composition was characterized by 16S rRNA gene sequencing.ResultsThe results show that the level of sperm total motility was decreased with the higher number of PS (β = −0.585, 95% CI = −1.071, −0.098), PVB (β = −0.775, 95% CI = −1.209, −0.341), and PET (β = −0.0.480, 95% CI = −0.937, −0.023). Importantly, the gut microbiota of men with abnormal sperm motility is dysregulated, and the gut microbiota plays a potential mediating role in the association between MP exposure and decreased sperm motility.ConclusionThis study provides evidence that MP exposure is associated with an increased risk of declined semen quality in men, and suggests a potential mediating role of gut microbiota in this relationship. These findings offer critical insights into the potential etiological clues of poor semen quality and contribute to a deeper understanding of the health risks and mechanistic pathways related to MP pollution.

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Bears 34, Seahawks 17.Eyes opened everywhere.Super Bowl thoughts rattling around the heads of Bears fans everywhere.Is it 1985 all over again?Holy cow, that was impressive. Let's get to the grades:QUARTERBACK — ASeventeen plays. Eighty yards. Eight and a half minutes. Against the top-ranked defense in the NFL — and in one of the toughest environments for a road team in sports — Caleb Williams calmly, coolly directed the first touchdown drive allowed by the Seahawks on an opponent’s opening possession in 27 games. It was a monster drive that said, “We’re here. More importantly, I’m here. Get to know me.” Williams got Colston Loveland going, then Luther Burden, then Rome Odunze. He kept the ball out of harm’s way. On his best play, he stepped his tree-trunk legs out of the grasp of Pro Bowl tackle Leonard Williams’ and hit Odunze for 22 yards on the third-quarter drive that put the Bears up 20-9. “Superstar” is the word now — go ahead and use it freely. Caleb Williams became the first player with 200+ passing yards against the Seahawks this season on this playpic.twitter.com/eBATND2yrE— Underdog NFL (@UnderdogNFL) November 3, 2026 RECEIVERS — B-PLUSOutside of tight end Loveland’s fourth-quarter fumble that set up the Seahawks for a 25-yard touchdown drive and two-point conversion to make it a 20-17 game, it was a great night for the pass catchers. Odunze claimed the deep middle as his territory, even making another of his apparently signature catches by reaching far behind his body — against its momentum — to snare a bullet. Burden, who had a 1-yard touchdown among his seven catches, continues to be open whenever Williams looks for him. Loveland, who also had seven catches, has put his slow start to the season deep in the rearview mirror. You just can’t put the ball on the ground, though.RUNNING GAME — BWhat a grind it was to get anything going on the ground against a team that hasn’t allowed a 100-yard rusher in its last 37 games. But the Bears converted a big fourth-and-one on their opening drive, D’Andre Swift getting five yards over the right side of the line (where have we seen that before?). And by the end, even though Swift averaged 2.6 yards per carry, he had 69 yards and three touchdowns and, lordy, you’d take that 17 weeks a season if you could.DEFENSIVE LINE — ANo need to ask on Tuesday why every kid in Bears country seems to be going to school with bright orange sleeves showing. It’s because defensive tackle Jeffery Simmons is their new hero. The brand-new Bear had an instant and major impact, recording his first sack with the team, helping linebacker Devin Bush blow up a screen pass, creating steady pressure and yapping nonstop at the Seahawks. Man, what attitude! Montez Sweat was similarly disruptive, exactly what the Bears hoped for in pairing him with his former college teammate. Austin Booker and James Lynch earned props, too, and not just because Booker tipped a pass that Lynch intercepted in nails-in-the-coffin time.REST OF THE DEFENSE — A-MINUSLinebacker Bush was everywhere, from hammering QB Sam Darnold with a huge hit on a scramble to sacking him later on. The Seahawks just plain couldn’t run the ball. Cornerback Tyrique Stevenson took his eyes off Jaxon Smith-Njigba for a beat and got toasted for a 43-yard touchdown as a result. Corner Jaylon Johnson whiffed on another routine-looking tackle attempt, allowing Smith-Njigba to run 21 yards after a catch. On the whole, though, well done by all.SPECIAL TEAMS — A-MINUSBooker’s field-goal block was one of the biggest plays of the game, keeping the lead at 11. Cairo Santos was pure on every kick, including a pair of field goals. Does anybody in the league go harder in punt coverage than Jahdae Walker? Near disaster came when Tory Taylor’s first punt was deflected; luckily for the Bears, it bounced and rolled and ended up going for 45 yards anyway.COACHING — ABen Johnson’s best regular-season win? The Bears looked as good as any team has in any game this season. To pull that off in Seattle required top-notch preparation, no doubt. Related Bears’ big plan coming together beautifully as 34-17 win over Seahawks pushes them to best start since 2012 Bears prove they belong among NFC’s elite with decisive 34-17 win vs. defending champs

Trey Campbell had 20 points, eight assists and six rebounds to lead Utah to a come-from-behind 66-63 win over Long Beach State in the season opener fo

BackgroundPathological response and survival following neoadjuvant PD-1 inhibitor plus chemotherapy in locally advanced gastric cancer (LAGC) are heterogeneous, and tumor biomarkers do not capture host endocrine, nutritional, or inflammatory status. We developed a pretreatment Hormonal-Nutritional-Immune Score (HNIS) based on 12 routine blood indicators.MethodsThis multicenter retrospective cohort enrolled 342 patients with cT2-4bN_anyM0 gastric or gastroesophageal junction (GEJ) adenocarcinoma treated with at least 2 cycles of PD-1 inhibitor plus platinum-based chemotherapy at 4 Chinese centers between December 2019 and January 2023, with patients allocated to a training cohort (n=206), an internal validation cohort (n=68), and an external validation cohort (n=68). HNIS assigned 1 point for each of 12 hormonal, nutritional, and inflammatory abnormalities; patients were stratified as Low (0 to 2), Intermediate (3 to 5), or High risk (6 or greater). The primary endpoint was major pathological response (MPR). Logistic regression, Cox regression, Kaplan-Meier analysis, and discrimination analyses were used. Additional analyses assessed treatment interactions, individual components, LASSO-derived weights, and alternative group boundaries using repeated nested cross-validation.ResultsThe median age was 62 years, 233 patients (68.1%) were male, and the median HNIS was 3 (IQR 2 to 5); 138 (40.4%) were Low risk, 121 (35.4%) Intermediate, and 83 (24.3%) High risk. MPR rates declined from 67.4% in Low risk to 46.3% in Intermediate and 20.5% in High risk patients (P<0.001), and grade 3 or higher immune-related adverse events (irAEs) increased from 7.2% to 9.9% to 26.5% (P<0.001). Each one-point HNIS increase was independently associated with lower odds of MPR (adjusted OR 0.68, 95% CI 0.61 to 0.76; P<0.001). At a median follow-up of 52.5 months, 3-year DFS was 69.6%, 58.7%, and 24.1%, and 3-year OS was 94.9%, 87.6%, and 69.9% across the 3 groups (both log-rank P<0.001). The HNIS score achieved AUCs of 0.725, 0.736, and 0.753 for MPR prediction in the training, internal, and external validation cohorts, outperforming a clinical model based on stage, PD-L1, and MMR (AUCs 0.554 to 0.611; DeLong all P<0.05). In supplementary repeated cross-validation, the equal-weight score had an AUC of 0.733, compared with 0.704 for a nine-component LASSO model.ConclusionsA pretreatment HNIS based on routine blood tests independently predicts MPR, severe irAEs, DFS, and OS in patients with LAGC receiving neoadjuvant PD-1 inhibitor plus chemotherapy, and may refine pretreatment risk stratification beyond conventional staging and tumor biomarkers.

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Robert Wright III scored 33 points to lead five BYU players in double figures as the No. 25 Cougars handed Ohio State a 94-83 loss on Monday in Salt L

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