From California native wildflowers to historic Midcentury Modern design, this guide offers details about spring garden tours in Southern California.

Loader package for the cancer-image-v00 asset.

As readers of this blog know, I am not a fan of most of President Trump's economic policy, especially regarding international trade. But today the president made an excellent choice for the new chair of the Federal Reserve. I have known Kevin Warsh for more than two decades, and I expect him to be a superb leader of the central bank.

If you've ever run the same app in multiple environments, you know the pain of duplicated configuration. Agent swarms have the same problem: the moment you try multiple orchestrators (LangGraph, Strands, OpenAI Swarm), your agent definitions start living in different formats. Prompts drift. Model settings drift. A "small behavior tweak" turns into archaeology across repos. AI behavior isn't code. Prompts aren't functions. They change too often and too experimentally to be hard-wired into orchestrator code. LaunchDarkly AI Configs lets you treat agent definitions like shared configuration instead. Define them once, store them centrally, and let any orchestrator fetch them. Update a prompt or model setting in the LaunchDarkly UI, and the new version rolls out without a redeploy.

SynthesisDOI: 10.1055/a-2824-3736This short review highlights recent advances in the enantioselective gold-catalyzed cycloisomerization of 1,6-enynes as an efficient strategy for accessing oxa- and aza-bicyclo[4.1.0]hept-4-enes as well as bicyclo[3.1.0] hexane derivatives. Emphasis is placed on the development of chiral gold catalysts and tailored substrate designs that enable high levels of chemo-, regio-, and stereocontrol despite the linear coordination geometry of gold(I). Mechanistic insights, including ligand effects and secondary interactions such as hydrogen bonding, are discussed to rationalize selectivity trends. The review also illustrates how these methodologies have enabled concise syntheses of biologically relevant molecules and hedonic compounds, underscoring the growing maturity and synthetic relevance of asymmetric gold catalysis.[...]Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Abstract | Full text

To the Editor Srinivasan et al reported relatively impressive performance of OpenAI o1 on an ophthalmology subset of questions from the Medical Multiple-Choice Question Answering (MedMCQA) dataset (6990 multiple-choice questions) and compared it with other contemporary large language models (LLMs). Their report advances the conversation on model accuracy and usefulness in eye care.

Alias for py2ddoc — decode and verify French ANTS 2D-Doc barcodes

In Reply We thank Kameda and Kaneko for their thoughtful comments on our recent article benchmarking OpenAI’s o1 large language model (LLM) performance on ophthalmological knowledge and reasoning tasks against that of previous general LLMs. Pertaining to the query on the LLM’s temperature setting, we would like to clarify that we evaluated the LLM at a standardized temperature of 0. However, we did not set the temperature of the o1 model to 0, mainly because OpenAI, at least at the time of our evaluation, did not allow users to change the temperature setting of o1. In fact, the temperature and top_p hyperparameters are not available for OpenAI’s reasoning models, including o1. Consequently, we evaluated o1 using its default configuration. We acknowledged this as a limitation of our study.

THURSDAY, March 19, 2026 — Late-night study sessions and the constant hum of social media make high school a stressful time, and a new study suggests that stress is contributing to a growing weight and health crisis. Researchers from Florida...

Screen grabs from the “Let’s Buy the Seahawks” initiative showing the proposal, center, and a receipt for a share. (LetsBuytheSeahawks.org) A new proposal to buy the Seattle Seahawks has been launched by a fan of the team who thinks such a community treasure should be owned by all of the 12s rather than one super rich billionaire. Abel Charrow‘s “Let’s Buy the Seahawks” website is a fun little distraction for any fans still nursing a Super Bowl hangover or lamenting the loss of some key players in this week’s free agency transactions. Charrow is a Seattle-based partner at Extra Good Studio, a collective of creatives that operates as a branding studio. As a longtime fan of the Seahawks, he was looking for a way to spark some interest in alternative ownership models now that the Paul Allen estate has put the team up for sale. But Charrow admits the effort is more tongue in cheek than it is a serious bid to become NFL franchise owners, even if he finds the shareholder model of the Green Bay Packers attractive. “Without being too on the nose, it’s sort of a criticism of billionaires and just how absolutely insane an amount of money it requires to buy something of that size,” Charrow told GeekWire during a phone interview Tuesday. “On some level, that’s what I wanted to highlight.” The site proposal calls on fans to raise a $12 billion bid, which is not an unrealistic price tag but maybe a few billion more than the Hawks will eventually command. At one share per person, everyone gets an equal stake. If all 780,995 residents of Seattle pitch in, that’s $15,365.02 each. The cost would drop as more fans across Washington state, the Pacific Northwest and beyond contribute. On Tuesday afternoon, 153 share-Hawks had been spoken for, including one by me. That put my investment at the time at around $79 million. I received a digital “receipt of intent,” but, sorry, I’m not good for that kind of money. Abel Charrow, left, is joined by his friends and fellow Seattle Seahawks fans Thomas Wicker-Fetzer, center, and Bryce Wilson at the team’s Super Bowl celebration at Lumen Field on Feb. 11. (Photo courtesy of Abel Charrow) Charrow lived in New Mexico as a kid without a pro sports team to root for. When he moved to Seattle it was a big deal to become a Seahawks fan. And when he moved again to L.A. to attend USC, he was there during the Pete Carroll era. Again he ended up back in Seattle, at the same time Carroll became the Hawks head coach and won the team’s first Super Bowl championship. This year, Charrow was equally excited cheering on USC alum Sam Darnold, the Seahawks’ newest Super Bowl-winning quarterback. Charrow doesn’t consider himself a technically proficient person. He got an MBA in technology management from the University of Washington last year because he felt the need to “skill up.” “In a way, it was a big experiment in vibe coding, to use a popular word these days,” Charrow said of the Hawks site he built. He explored a few different programs including Cursor, Replit, and Codex, and said Claude Code is next. There are a few easter eggs built into the site if fans bother to click around. Clicking on the Space Needle triggers a “Beast Quake” and clicking on a dangling football launches a Jason Myers simulator that lets fans kick field goals. The idea of community ownership has been kicked around since the estate of Allen, the late Microsoft co-founder, announced that the team was being sold in accordance with his wishes. Seattle-based tech startup Arrived is gauging fan interest in acting as a collective that would hold a private equity stake in the Seahawks. More than 12,000 fans have shown $113 million worth of potential interest. Beyond that, most fans and sports prognosticators expect another billionaire to eventually step up. The list of such people who also have ties to Seattle includes a who’s who of tech, including former Microsoft CEO Steve Ballmer and Amazon founder Jeff Bezos. Bill Gates has said that he’s not interested. Charrow isn’t keeping track of names or contact information of fans who actually signal their interest in owning a share of the team, admitting that it’s “mostly an art project.” “If people are serious about it, they can subscribe and I’ll keep them posted on the progress,” he said. “Hopefully it’ll start some conversation and maybe people will get this idea of … ‘why not?'”

Rainelle Krause, a coloratura soprano whose signature role was the Queen of the Night in "The Magic Flute," died Tuesday at 37, her family confirmed.

Cesar Chavez, the iconic labor leader, is accused of sexually assaulting Dolores Huerta, with whom he co-founded the United Farm Workers, in the 1960s.

Here is the link. I paste a copy below.The Federal Reserve’s independence and the public’s perception of that independence are critical for economic performance, including achieving the goals Congress has set for the Federal Reserve of stable prices, maximum employment, and moderate long-term interest rates. The reported criminal inquiry into Federal Reserve Chair Jay Powell is an unprecedented attempt to use prosecutorial attacks to undermine that independence. This is how monetary policy is made in emerging markets with weak institutions, with highly negative consequences for inflation and the functioning of their economies more broadly. It has no place in the United States whose greatest strength is the rule of law, which is at the foundation of our economic success.SIGNATORIESBen S. Bernanke served two terms as Chair of the Board of Governors of the Fed, as well as Chair of the Council of Economic Advisers under President George W. Bush.Jared Bernstein served as Chair of the Council of Economic Advisers under President Joe Biden.Jason Furman served as Chair of the Council of Economic Advisers under President Barack Obama.Timothy F. Geithner served as the 75th Secretary of the Treasury under President Barack Obama, as well as President and Chief Executive Officer of the Federal Reserve Bank of New York.Phil Gramm served as Chairman of the Senate Banking Committee.Alan Greenspan served five terms as Chair of the Board of Governors of the Fed, first appointed by President Ronald Reagan and then reappointed by Presidents George H.W. Bush, Bill Clinton, and George W. Bush. He also was Chair of the Council of Economic Advisers under President Gerald Ford.Glenn Hubbard served as Chair of the Council of Economic Advisers under President George W. Bush.Jacob J. Lew served as the 76th Secretary of the Treasury under President Barack Obama.N. Gregory Mankiw served as Chair of the Council of Economic Advisers under President George W. Bush.Henry M. Paulson served as the 74th Secretary of the Treasury under President George W. Bush.Kenneth Rogoff is the Maurits C. Boas Professor of International Economics at Harvard University and former chief economist of the International Monetary Fund.Christina Romer served as Chair of the Council of Economic Advisers under President Barack Obama.Robert E. Rubin served as the 70th Secretary of the Treasury under President Bill Clinton, after serving as the first director of the White House National Economic Council.Janet Yellen served as the 78th Secretary of the Treasury under President Joe Biden, Chair and Vice Chair of the Board of Governors of the Fed, Chair of the Council of Economic Advisers under President Bill Clinton, and President and CEO of the Federal Reserve Bank of San Francisco.

Cross-platform Python client for KMBox Net devices

With 36 of its planned 42 stories now poured, the Guitar Hotel Las Vegas is steadily nearing structural completion and making progress toward its scheduled late-2027 opening act .

This diagnostic study investigates if an artificial intelligence algorithm can diagnose bronchopulmonary dysplasia or pulmonary hypertension in the retinal images of preterm infants obtained during retinopathy of prematurity screening examinations.

Econometric analysis engine for agents. OLS, FE, IV/2SLS, DiD, RDD, Event Study, Causal Forest.

The Nationals announced a trio of camp cuts this morning. Starter Josiah Gray, outfielder Robert Hassell III and reliever Julian Fernández will all begin the season in the minors. Gray was an All-Star in 2023 after making 30 starts with a 3.91 ERA. He was hit hard over two starts the following season and underwent UCL surgery in July. Gray didn’t pitch in MLB last year as he rehabbed the injury. He made a trio of abbreviated starts in the minors to at least get some game action in before the offseason began. The 28-year-old has taken the ball twice in camp. He pitched 4 2/3 frames of one-run ball with five strikeouts. The Nationals will continue his buildup as a depth starter at Triple-A Rochester. Mitchell Parker, Andrew Alvarez and Jake Eder are also on the 40-man roster but beginning the season in the minors. Gray’s demotion seemingly positions Jake Irvin as Washington’s fifth starter. Cade Cavalli will take the ball on Opening Day against Matthew Boyd and the Cubs. Miles Mikolas, Foster Griffin and Zack Littell signed one-year free agent deals that should lock them into the rotation. Irvin led the team with 180 innings last season, but he was tagged for an ugly 5.70 ERA while striking out fewer than 16% of opponents. That left him to compete for a rotation role this spring. To his credit, the 29-year-old righty has had an excellent camp. Irvin has allowed just two runs while striking out 15 across 13 1/3 innings. He has toyed with a deeper pitch mix, throwing more cutters and sliders after leaning mostly on his fastballs and curveball last year. Hassell, a former top 10 pick who came over from San Diego in the Juan Soto trade, hit .223/.257/.315 over his first 70 MLB games last year. He struck out nine times while walking just once in 29 spring plate appearances. Hassell heads back to Triple-A, where he had a strong season (.310/.383/.456 in 76 games) a year ago. The Nationals have James Wood, Jacob Young and Daylen Lile assured of spots in the MLB outfield. Dylan Crews will presumably be in there as well, though it’s at least conceivable that the Nats could determine he’d benefit from Triple-A reps. The former second overall pick limped to a .208/.280/.352 showing in his first full MLB season. He has only picked up three hits while striking out 10 times in 32 plate appearances this spring. Offseason waiver pickup Joey Wiemer has also had a rough camp and still has an option remaining.