Florida voters will choose Tuesday between Republican Byron Donalds and Democrat David Jolly in a governor’s race that is testing the endurance of the state’s conservative shift in recent years. A Democrat hasn’t won the Florida governor’s race since Lawton Chiles in 1994. But Jolly, a former Republican congressman from Tampa, switched parties and campaigned as a centrist ready to move the state beyond years of fierce culture wars stoked by outgoing Gov. Ron DeSantis. Donalds, a congressman from southwest Florida who won the Republican nomination with President Donald Trump’s backing, has sought to define Jolly as an out-of-touch liberal. He would be Florida’s first Black governor and has throughout the campaign reached out to Black voters who have overwhelmingly backed Democrats. The results will signal whether Trump’s unpopularity, which has weighed down Republicans across the U.S., will extend into his adopted home state. Democrats head into the election heartened by a string of special election wins over the past year from Miami to Trump’s backyard in Palm Beach. Beyond the national political environment, the race has centered on issues including high prices and the cost of homeowners insurance, a particularly salient issue in a state with a history of being ravaged by hurricanes. Florida spent a generation as America’s prized political battleground, where the interests of big cities, agricultural towns, freshly arrived retirees and diverse Latino communities collided in elections often decided by fractions of a percentage point. That reputation began to fade under DeSantis, who won his first race in 2018 by less than half a percentage point. But once he was in office, he leaned into debates over race and gender — signing, for instance, legislation often labeled by critics as “ Don’t Say Gay ” that bars instruction on sexual orientation and gender identity in kindergarten through the third grade. By the time he ran for reelection in 2022, DeSantis won in a nearly 20-percentage-point landslide that left the state’s Democrats in shambles. Jolly faces steep hurdles in his effort to lead the party’s rebound. Republicans have a roughly 1.5 million voter registration advantage, and Donalds has dominated Jolly in fundraising. Seeking to overcome those challenges, Jolly has campaigned in Florida’s Democratic strongholds, like Broward County, along with traditionally Republican parts of central Florida and the Panhandle. Donalds has maintained a steady confidence throughout the campaign. He balanced his support for Trump, including appearing with him at a recent rally, with efforts to create some distance, such as minimizing references to the president on his website. Regardless of who wins the governor’s race, they will almost certainly have to work with a legislature where Republicans will hold majorities. If Jolly proves competitive, Democrats have hoped they could at least break the GOP’s supermajority in the legislature, giving them greater leverage in the crafting of bills.

The molecular complexity of the hematopoietic microenvironment (niche) and its response to immune stress remain largely unknown. Here, we establish the transcriptional profile of the lymph gland, the Drosophila hematopoietic organ, and its associated niche, the posterior signaling center, at single-cell resolution and at different time points following an immune challenge. Among blood cells, we identify permanent cellular states present with and without stress, but also transient states specific to the immune response, which correspond to dividing cells primed to differentiate into dedicated effector cells. The niche itself is a heterogeneous cell population, and most niche cells undergo dynamic transcriptional remodeling following immune stress. Finally, we identify two new players involved in the hematopoietic stress response: the immune deficiency pathway and the cholecystokinin-like receptor, both of which are expressed in niche cell subsets during immune stress conditions. This molecular atlas of lymph gland cells at different time points after an immune challenge provides new insights into the control of stress hematopoiesis by discrete niche cell subsets

I have a course marketplace business called HOSTORE (Host Your Knowledge) for Nigeria. I want to launch Android and iOS apps in 5 days. WHAT I HAVE: - FlutterFlow LMS/Udemy template already bought (access will be provided)... (Budget: $100 - $200 USD, Jobs: CSS, Graphic Design, HTML, PHP, Website Design)

WASHINGTON (AP) — Six months ago, the South Carolina U.S. Senate race was expected to be another straightforward campaign for incumbent Lindsey Graham and his dominant Republican Party. But Graham’s sudden death in July and the elevation of his political neophyte sister Darline from a placeholder role to seeking her own six-year term have roiled the race. Now supporters of Democrat Annie Andrews can envision something that seemed impossible in this century of double-digit Republican wins — flipping a Senate seat in one of the nation’s most reliable GOP strongholds. Whoever wins will be the first woman elected to represent South Carolina in the U.S. Senate. But that bit of history has taken a backseat to whispers that have grown into actual predictions that Andrews could be the first Democrat since 1998 to win a statewide race for the U.S. Senate or the governor’s office. Darline Graham went from political sibling to stand-in senator Darline Graham, by her own admission, is a reluctant candidate. She was abruptly thrust into the political spotlight after her brother, a U.S. Senate stalwart, died seeking his fifth term. Republican Gov. Henry McMaster appointed Darline Graham to finish her brother’s term in a widely hailed move, given the siblings’ close relationship. Lindsey Graham helped raise his younger sister after their parents’ early deaths. Darline Graham’s decision to seek a full six-year term was more surprising. The snap primary, organized just a month after Lindsey Graham’s death, drew some of the top names in South Carolina politics. President Donald Trump wanted Darline Graham in the Senate, and he immediately and forcefully backed her. The president had feuded with her brother at times but saw Lindsey Graham as an ally during his second White House term, particularly on the war with Iran. As Darline Graham and U.S. Rep. Ralph Norman, an occasional Trump critic, battled it out in a primary runoff, the president campaigned for her in the state and returned twice in the final weeks before the election. But that presidential backing may be eroding Graham’s support from both sides. It bothers independent voters unhappy with Trump’s second term and Norman supporters on the right who are unhappy that the president interfered in what should be a decision left up to the state’s voters. Both groups are uneasy about Graham’s inexperience and the prospect of turning the seat into a Graham family dynasty. In a primary debate, Graham was asked whether the U.S. has a national security interest in Taiwan and the South China Sea — a longstanding contention of both Democratic and Republican administrations. She struggled to answer before admitting, “National security is not my thing.” As Republican-affiliated groups across the country reshuffled last-minute campaign spending, Senate Republicans’ primary super PAC sent reinforcements to deep-red South Carolina to shore up Graham, even as Republicans said they remained confident they would retain the seat. Annie Andrews retooled her campaign to face Darline Graham Andrews had already been campaigning for more than a year and had won her primary outright when Lindsey Graham died, forcing her to rejigger a general election plan centered on ousting the incumbent. Andrews has benefited from South Carolina’s leadoff status on Democrats’ 2028 presidential nominating calendar. Former Transportation Secretary Pete Buttigieg and Arizona Sen. Mark Kelly have visited the state, boosting her visibility and their own. But in recent weeks, Andrews has run an independent campaign and has rarely appeared alongside prominent Democrats from South Carolina or elsewhere. She has focused on economic problems and says Graham will be like her brother, a part of the same Washington cabal that enriches only itself and cares little about the people back home. When they met for their sole debate last month, Graham and Andrews traded barbs over the economy, war with Iran and artificial intelligence. But they mostly argued over who was less qualified for the South Carolina Senate seat. Andrews came up short in a 2022 challenge to Rep. Nancy Mace but has remained visible since, though she’s never held office or run statewide. Graham fended off Andrews’ accusation that the Republican was seeking to ride her brother’s political coattails, saying she had legally kept her maiden name to maintain a connection to her parents, both of whom died when she was young. “Thank you for bringing up a horrible, tragic memory for me,” she added. It’s been decades since South Carolina elected a Democrat to the US Senate A New York Times/Siena poll conducted in October appeared to show a close race. But polls also showed an apparently close race in 2020, when Lindsey Graham, Democrat Jaime Harrison and outside groups supporting their campaigns spent hundreds of millions of dollars in South Carolina’s most expensive election. In that reelection, Lindsey Graham’s last, the Republican sailed back into office by a 10-percentage-point margin. The last Democrat elected to a Senate seat in South Carolina was Fritz Hollings, who won his final term in 1998. Since then, Republicans have held both Senate seats, and only one Democrat — Jim Clyburn — represents the state in the U.S. House. Republicans have benefited from straight-ticket voting, which allows voters to choose all GOP candidates on their ballot. The race for South Carolina’s open governor’s seat hasn’t appeared as close as the U.S. Senate contest. Libertarian and Constitution Party candidates are also on the general election ballot. ___ Collins reported from Columbia, South Carolina. ___ Kinnard can be reached at http://x.com/MegKinnardAP

BackgroundPulmonary dysfunction is common in single ventricle (SV) patients with Fontan circulation, yet the prevalence and clinical relevance of true restrictive lung disease remain poorly characterized as most studies relied on spirometry alone. This study comprehensively assessed lung function using spirometry and body plethysmography, examined its relationship with cardiac magnetic resonance (CMR)-derived lung volumes, evaluated its impact on exercise capacity, and identified clinical correlates of restrictive physiology.MethodsIn this prospective, single-centre study, 31 children and adolescents with Fontan circulation underwent spirometry, body plethysmography, cardiopulmonary exercise testing (CPET), and CMR. Restrictive lung function was defined by reduced (

“Dancing With the Stars” celebrated the magic of Disney during the Monday, Nov. 2, episode, but one celebrity contestant didn’t get a happily ever after.

Here are the top Stories from every Major League team courtesy from our friends at . Note - this page updates throughout the day - come back later today for the latest news.

Medium

With new recycling hubs and six mill partnerships, the French textile recycler is laying the groundwork for regenerated polyester at scale—but says brands must help pull the circular system into existence.

A backyard fire that could have turned deadly is serving as a stark warning to Northeast Ohio homeowners as Ohio's fall burn ban remains in effect.

Micro- and nanoplastics (MNPs) have recently been detected in multiple human tissues, including the brain, raising concerns regarding their potential contribution to neuroinflammation and neurodegeneration. However, whether chronic exposure to MNPs is sufficient to perturb the healthy central nervous system remains unresolved. Here, we combined spatial transcriptomics, flow cytometry, blood-brain barrier analyses, microglial morphometry, inflammatory profiling, and behavioural testing to define how chronic oral exposure to micro- and nanoplastics affects the healthy young mouse brain. Spatial transcriptomics identified subtle alterations in cellular neighbourhood organisation and modest transcriptional remodelling across multiple cell populations, including endothelial cells and macrophages. Nevertheless, chronic MNP exposure did not cause detectable blood-brain barrier leakage, alter brain immune cell composition, induce overt microgliosis or astrogliosis, or trigger elevated cytokine production. Likewise, extensive behavioural phenotyping across oral gavage and dietary exposure paradigms failed to reveal detectable impairments in locomotion, anxiety-like behaviour, cognition, or fear conditioning. Together, our findings demonstrate that, under the chronic oral exposure conditions and endpoints tested, healthy young mice display substantial resilience to MNP exposure in the brain. These findings establish an important baseline for future studies investigating whether inflammatory, metabolic, or neurodegenerative conditions sensitize the brain to MNP-associated pathology.

03-11-2026 07:00 Canada and Europe want to work closer together. Many people in Canada prefer to buy things from Europe instead of the United States. Trade with the United States is changing. European leaders are talking about how to help each other more. They want to share energy, keep prices low, and help students study in different countries. Some big countries in Europe say that the rules are not ready for a special membership. But they still want to be strong friends. Working together helps both Canada and Europe stay safe, protect their businesses, and keep their people happy. Difficult words: share (to give a part of something to others, or to use something together), membership (when a country or person belongs to a group, club, or organization), protect (to keep someone or something safe). You can watch the original video in the Level 3 section. The post Canada and Europe want to work closer together – level 1 appeared first on English news and easy articles for students of English.

02-11-2026 07:00 South Africa tests a very long train. The train is 7.6 kilometres long. It has 696 empty wagons. It goes 860 kilometres from the ocean to a mine. Electric and diesel engines help move the big train across the country. The company says that this is now the longest train in the whole world. It is longer than a famous train in Australia from many years ago. That train is 7.2 kilometres long. People believe that this big test is a great step for their country’s trains and business. It will help move heavy things across long distances much faster and better in the future. Difficult words: wagon (one of many parts of a train which carries things or materials), mine (a deep hole in the earth from which workers get minerals, stones, or other materials), distance (how far two places or objects are from each other). You can watch the original video in the Level 3 section. The post The longest train – level 1 appeared first on English news and easy articles for students of English.

The Notting Hill pop-up, running Nov. 12 to 22, is part of a broader move toward physical retail as the French brand continues its funding round.

Viridian Anonymous (not verified) Tue, 11/03/2026 - 00:25 field_thread_url https://cafepharma.com/boards/threads/viridian.713969/ board name Biotech Startups

Grammy Award-winning producer and hip-hop icon Timbaland (born Timothy Mosley) has filed a high-stakes $15 million lawsuit against his former management team, accusing them of financial mismanagement, breach of fiduciary… The post Timbaland Files $15 Million Lawsuit Against Former Managers Alleging Financial Mismanagement and Theft appeared first on .

Medium

The Los Angeles Lakers didn’t have much time to celebrate their win over the Toronto Raptors as they were back in action on Monday night, taking on the Miami Heat at Crypo.com Arena in the second night of a back-to-back. They didn’t look like the tired team though as Luka Doncic continued his absolute tear to begin the season and the Lakers picked up another win to improve to 6-2 on the year. Lakers 138, Heat 117: key takeaways Another good start for Lakers The Lakers have been getting out to quick starts all season, and that was again the case in this one. Doncic leads the NBA in first quarter scoring by a mile and in this one, he had a pair of early triples to get him going and had 16 points overall in the first quarter. Both teams were shooting it well from deep early, which is how the Heat stayed within striking distance. But a nice spurt to end the quarter by L.A. gave them a 37-30 lead. Defense optional With both teams catching fire, they were essentially going back and forth exchanging buckets for much of the first half. They both shot 10-of-20 from 3 and scored 70-plus points with the Lakers leading 79-72 at the break. Luka Doncic does it again Doncic has been playing at an MVP level to begin the season and he continued his ridiculous tear. He came out firing in the third quarter with a three-point play and then a triple as the Lakers began to build their lead. It was all Doncic from there as he was either scoring or creating wide open looks for his teammates. He found Walker Kessler for a dunk and then connected from deep once again to get the lead up to 20, although the Lakers wound up taking a 111-93 lead into the fourth quarter. The Lakers have greatly struggled with Doncic on the bench the last few games, but that was not the case in this one as they held their own to begin the fourth. Then, Doncic returned and picked up where he left off as the superstar recorded his fourth 40-point game in the last five outings and the Lakers had no issue closing out the easy win. What’s next for the Lakers The Lakers will now hit the road to take on the Sacramento Kings on Wednesday before returning home and hosting the Portland Trail Blazers on Friday in a rematch from a fun contest last week. If you love our reporting, choose LakersNation.com as a preferred source on Google.

Vortex-induced motion (VIM) is a primary cause of fatigue damage to the mooring systems and risers of semi-submersible platforms. For multi-column platform structures, flow refraction and diffraction around individual columns generate complex ambient flow fields, and the underlying VIM mechanisms have not been fully clarified. In this work, towing tank model tests are performed to investigate the effects of column spacing ratio (S/D) on the VIM responses of a semi-submersible platform under a 45°current incidence angle, focusing on the quantitative correlations of motion amplitudes and frequency characteristics with spacing ratio and reduced velocity. The experimental results indicate that distinct lock-in phenomena appear in platform sway motion under all tested S/D conditions. According to frequency characteristics, the VIM evolution can be classified into three stages: pre-lock-in, lock-in and post-lock-in. In particular, the frequency coupling behavior in the post-lock-in stage is highly sensitive to column spacing ratio. Although all S/D cases exhibit consistent amplitude variation trends with reduced velocity, significant differences are observed in amplitude magnitudes. Under identical test conditions, larger column spacing ratios generally induce more intensive VIM responses, with a maximum sway amplitude difference of 30.8%. Further power spectral density (PSD) analysis verifies that surge galloping occurs in the post-lock-in region, while yaw galloping is synergistically dominated by reduced velocity and column spacing ratio. Although large column spacing can mitigate inter-column flow interference, such layout schemes substantially increase the risks of multi-degree-of-freedom VIM and galloping excitation. Therefore, simply increasing column spacing is not an effective measure for VIM suppression in practical semi-submersible platform design. The optimal S/D should be comprehensively determined by balancing the sway lock-in range and the critical onset velocities of surge and yaw galloping, as well as fully considering the current spectrum of the operating sea area. This multi-objective design strategy can achieve effective overall control of platform VIM risks.

02-11-2026 15:00 Actors Jack Lowden, Josh O’Connor, and Callum Turner are trying to become the new James Bond. Big tests are happening now to see who is best at fighting, talking, and acting on camera. Jack Lowden is the favorite right now, but other actors also have a chance. Leaders want to pick a strong actor from Britain or a connected country. Fans around the world are excited to learn who will play the famous spy. The final news about the new James Bond will come around Christmas time. Difficult words: favorite (the person who many people think will win), excited (very happy and keen on something), spy (a person who gets secret information). You can watch the original video in the Level 3 section. The post Who will be the next James Bond? – level 1 appeared first on English news and easy articles for students of English.